Stroke
Conditions
Interventions
Aspiration Group:no
Non-aspiration group :no
Healthy volunteer:no
Low frequency group:rTMS
High frequency group:rTMS
Sponsors
Third hospital of Sun Yat-sen university
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria were: ? no heart, serious diseases of the lung, liver, pancreas, kidney and other organs, no metal implants in the body, voluntary signing of informed consent; ? Healthy volunteers were screened with Eating Assessment Tool (EAT-10) without swallowing disorder; The patient's EAT-10 screening score was more than 3 points, and Videofluoroscopy Study (VFSS) confirmed dysphagia in pharyngeal stage. Penetration-Aspiration Scale (PAS)<5 is classified as aspiration for non-aspiration patients, and PAS=5 is classified as aspiration patients. ? Healthy volunteers had no mental or neurological history; Head MRI of patients with subtentorial stroke confirmed that the lesion site was brain stem or cerebellum. ? Age 30-75 years old; ? The healthy volunteers had no cognitive or speech dysfunction.
Exclusion criteria
Exclusion criteria: Exclusion criteria were: ? complicated with multiple neurological diseases such as cerebral cortex or subcortical, brainstem, cranial nerve; ? The patients had taken gastrointestinal motility agents, H2 blockers, sedatives, analgesics, antidepressants and anticholinergics within 1 month before enrollment, and had a history of throat tumor, gastrointestinal motility disease, and severe cardiopulmonary and renal complications; (3) Implantation or keeping metal objects in the body, installation of electronic devices such as cardiac pacemakers, and unstable medical conditions can not cooperate with the examination of patients; ? Have severe claustrophobia, refuse to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| breath-swallowing coordination; | — |
Secondary
| Measure | Time frame |
|---|---|
| VFSS;rsfMRI; | — |
Countries
China
Contacts
Public ContactZu-lin Dou
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed