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Safety and Effectiveness of Del Nido cardioplegia in myocardial protection with long-term cardiac surgery: a prospective randomized controlled trial

Safety and Effectiveness of Del Nido cardioplegia in myocardial protection with long-term cardiac surgery: a prospective randomized controlled trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300071861
Enrollment
Unknown
Registered
2023-05-26
Start date
2023-06-01
Completion date
Unknown
Last updated
2023-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

adult heart disease

Interventions

Sponsors

Shanghai Chest Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 18 to 65 years; 2. Patients undergoing elective cardiac surgery with cardiopulmonary bypass. 3. aortic cross-clamping time greater than 120 minutes

Exclusion criteria

Exclusion criteria: 1. Patients who do not consent to join the study; 2. Patinets who have severe perioperative infection; 3. Emergent surgery; 4. Patients who require high dose pharmacological inotropic support before surgery; 5. Patients who require preoperative mechanical circulatory support such as intra-aortic balloon pump or extracorporeal membrane oxygenation; 6. Patient who need surgical ablation; 7. Patients who undergo deep hypothermic circulatory arrest surgery; 8. Patients who have pacemaker implantation or PCI one month before cardiac surgery; 9. Patients who have a history of abnormal thyroid function; 10. Patients who have a history of coronary artery disease.

Design outcomes

Primary

MeasureTime frame
cTn;

Secondary

MeasureTime frame
Automatic heart resuscitation;heart resuscitation time after cross-clamp;failure to wean from cardiopulmonary bypass;malignant arrhythmia;Myoglobin;CK-MB;LDH;CRP;cardioplegia volume;caridopulmonary bypass time;cross-clamp time;transfusion during surgery;transfusion postoperation;Vasoactive Inotropic Score (VIS);mechanical ventilation time;Length of ICU stay;Length of hospital stay;In-hospital mortality;Intraoperative Glucose Levels;Intraoperative potassium level;Intraoperative sodium level;Intraoperative calcium level;diastolic and contractile function of heart;pathology test of left atrial appendage;

Countries

China

Contacts

Public ContactSun Lin

Shanghai Chest Hospital

filibuster@shchest.org+86 189 3085 9596

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026