sepsis
Conditions
Interventions
Control Group:None
Sponsors
The First Medical Center of Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 75 years old, gender unrestricted. 2. Newly diagnosed sepsis patients with secondary intra-abdominal infection (such as appendicitis, cholecystitis, pancreatitis, digestive tract perforation caused by gastric or duodenal ulcers, iatrogenic anastomotic fistula, postoperative intra-abdominal bleeding, foreign body retention, etc.) during ICU hospitalization who meet the diagnostic criteria of the "2016 International Guidelines for the Management of Severe Sepsis and Septic Shock" (infection or suspected infection, and SOFA score = 2 points) and have been diagnosed for less than 48 hours.
Exclusion criteria
Exclusion criteria: 1. Pregnant women; 2. Those with immunosuppressive conditions, including a history of malignant tumors, long-term use of steroids or immunosuppressive drugs (including antifungal and antiviral drugs), HIV or other immunodeficiency diseases, and a history of organ transplantation; 3. Those who have used immunostimulants (such as thymopentin, interleukins, immunoglobulin, etc.); 4. Sepsis caused by primary intra-abdominal infection (without a primary lesion in the abdomen, but migrated from other parts to the abdomen); 5. ICU stay less than 24 hours; 6. Those who have been diagnosed with sepsis in an external hospital or other department before being transferred to the ICU.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Single-cell transcriptome sequencing of peripheral blood dendritic cells; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sequential Organ Failure Assessment;28-day ICU mortality rate; | — |
Countries
China
Contacts
Public ContactKANG HONGJUN
The First Medical Center of Chinese PLA General Hospital
Outcome results
None listed