Prostate cancer
Conditions
Interventions
Non-biopsy:Receiving radical prostatectomy without preoperative prostate biopsy
preoperative biopsy:Receiving radical prostatectomy with pathologically confirmed prostate cancer by preoperative prostate biopsy
Sponsors
Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
Eligibility
Sex/Gender
Male
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age > 60 2. The mpMRI indicated abnormal nodules (PI-RADS score >= 4) or PSMA PET/CT suspected tumor (PSMA-Rads score >= 4 and SUVmax >= 4) 3. Meet at least one of the four requirements: PSA>= 10ng/ml, 4ng/ml 0.20, PHI > 35 4. Clinical stage <= T4NxM0, and radical prostatectomy technically feasible 5. Can tolerate laparoscopic radical prostatectomy 6. Have the capacity of independent behavior and voluntarily sign the informed consent to be included in the group
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to surgery 2. Patients with a history of Prostate puncture or surgical 3. Patients with preoperative treatment including antitumor drugs for prostate cancer 4. Patients with Life expectancy less than 10 years 5. Patients with ECOG score > 2 6. Patients with poor compliance and other exclusion criteria identified by other researchers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prostate cancer detection rate;biochemical recurrence ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Surgical duration; Intraoperative bleeding volume;positive surgical margin;missed diagnosis ;ardent fever; Antibiotic usage days;Intraoperative intestinal injury; Postoperative urinary incontinence;Postoperative sexual function;hospitalization time;hospitalization cost;biomarker in immunohistochemical staining; | — |
Countries
China
Contacts
Public ContactShaogang Wang
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed