Helicobacter pylori
Conditions
Interventions
10-day vonoprazan-amoxicillin dual therapy group:10-day vonoprazan-amoxicillin dual therapy
14-day vonoprazan-amoxicillin dual therapy group:14-day vonoprazan-amoxicillin dual therapy
Sponsors
Wenchang People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age range from 18-70 years old; 2. H. pylori infection diagnosed by C13/ C14-urea breath test; 3. Without digestive diseases except dyspepsia and chronic gastritis, without surgical history, without history of serious cardiovascular,respiratory, endocrine (diabetes), kidney disease, blood disease; ( 4. In recent 3 months, patients without severe diarrhea (watery stool for more than 3 times a day and lasting for more than 3 days), without constipation (defecation less than 2 times a week and accompanied by difficulty defecating), without blood in the stool ; ? Informed and agreed to participate in the study
Exclusion criteria
Exclusion criteria: 1. With a history of H. pylori eradication; 2. Alcohol abuse, illicit drug use or drug addiction, or consumption of >21 units of alcohol per week (6300 mL beer, 525 mL spirits, or 2100mL wine) in the 12 months prior to screening; 3. Taking antibiotics, probiotics, PPI, antiviral/fungal drugs, NSAIDs, mucosal protectants, immunosuppressants or hormones in the past 3 months; 4.Taking laxatives or having acute gastroenteritis in the past 4 weeks; 5. Pregnancy and lactation; 6. Excessive obesity; 7. Allergy to penicillin or other drug in this study; 8. Currently participating in another clinical study; 9. Patients assessed as unsuitable by investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate;Safety;the change of gut microbiota; | — |
Countries
China
Contacts
Public ContactTingting Xu
Wenchang People's Hospital
Outcome results
None listed