hypertension
Conditions
Interventions
treatment group:Azisartan 40mg qd oral
control group:Amlodipine besylate 5mg qd
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. The age is 18-70 years old (including 18 and 70 years old), and the gender is not limited; 2. BMI >= 28kg/m2 (BMI= weight/height 2); 3. Patients diagnosed with grade 1 and grade 2 essential hypertension (SBP >= 140mmHg and/or DBP >= 90mmHg and SBP 14; LAVI > 34 mL/m2; TR > 2.8m/s meets both criteria).
Exclusion criteria
Exclusion criteria: 1. Secondary hypertension (renal parenchymatous hypertension, Cushing's syndrome, primary aldosteronism, pheochromocytoma, drug-induced hypertension, etc.); 2. Mean sitting blood pressure >= 180 mmHg and/or DBP >= 110mmHg, or patients with acute hypertension or subacute hypertension; 3. Allergy to CCBS or ARBS, and intolerance to amlodipine or azisartan ester (e.g. Angioedema); 4. Secondary obesity: hypercortisolism, hypothyroidism; 5. Severe arrhythmia and atrial fibrillation; 6. Coronary heart disease, heart failure, valvular heart disease, pulmonary heart disease, congenital heart disease, cardiomyopathy, hyperthyroid heart disease; 7. Diabetes mellitus; 8. Cerebrovascular diseases; 9. Patients with obvious clinical manifestations or signs of liver disease or screening visits with ALT > 2.5 x UNL and/or AST > 2.5 x UNL and/or total bilirubin > 1.5 x UNL; Severe renal dysfunction, eGFR = 35); 12. Patients deemed unsuitable for clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left atrial volume index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Global long axial strain of left ventricle;NT-proBNP; | — |
Countries
China
Contacts
Public ContactChen Gailing
China-Japan Friendship Hospital
Outcome results
None listed