Senile dementia
Conditions
Interventions
Observation group:N/A
Sponsors
The Second Hospital, Cheeloo College of Medicine, Shandong University
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 50 years old; 2. Patients with senile dementia, including Alzheimer's dementia, vascular dementia, frontotemporal dementia; 3. MMSE score <= 20 points; 4. Newly diagnosed patients with more than moderate dementia, or patients with more than moderate dementia who have been clearly diagnosed but have not been treated with memantine before; 5. A reliable caregiver.
Exclusion criteria
Exclusion criteria: 1. Allergic to the test drug or its related ingredients; 2. Patients with severe liver function impairment (ALT or AST level more than 3 times the upper limit of normal value); 3. Patients with severe renal function impairment (serum creatinine more than 3 times the upper limit of normal value); 4. Previous diagnosis of depression, bipolar disorder or other mental disorders; 5. Patients with poor compliance who cannot be treated according to the prescribed program; 6. Patients considered unsuitable for inclusion by other researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mini-mental state examination, MMSE; | — |
Secondary
| Measure | Time frame |
|---|---|
| Alzheimer's Disease Collaborative Study-Activities of Daily Living Scale, ADCS-ADL;Neuropsychiatric Symptoms Questionnaire, NPI;Morisky Medication Adherence Questionnaire score, MMAS-8; | — |
Countries
China
Contacts
Public ContactShunliang Xu
Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University
Outcome results
None listed