Autism spectrum disorder
Conditions
Interventions
Observation group 1:1Hz-rTMS stimulates right DLPFC
Observation group 2:10Hz-rTMS stimulates rTPJ
Observation group 3:10Hz-rTMS stimulates rTPJ
Control group:Pseudo-stimuli
Sponsors
Xuzhou Children's Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1. Age at enrollment: 3-6 years old, Han children; 2. Meet the diagnostic criteria for ASD in the revised fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR), as last revised on 18 March 2022; 3. The parents of the child agree and sign the informed consent form, and can cooperate with the treatment; 4. Complete clinical data; 5. Wechsler Intelligence Test >= 70 points; 6. Autism Interview Scale (CARS) >= 32 points; 7. Overall score from the Children's Sleep Habits Questionnaire (CSHQ) baseline > 41; 8. Impaired executive function: Preschool children's BREIF-P T score >= 65; 9. Right-handed; 10. No medication was taken during the study.
Exclusion criteria
Exclusion criteria: 1. Metal or electronic instruments near the irritation site of the coil; 2. History of epilepsy; 3. History of brain trauma, brain tumor, or other disease; 4. Have a serious heart condition or other major physical condition; 5. Diagnosis of other psychiatric disorders (e.g., attention deficit hyperactivity disorder, schizophrenia, and depression); 6. Other neurodevelopmental disorders, inherited metabolic diseases, or severe neurological disorders; 7. Previous treatment for TMS; 8. Serious incomplete case data; 9. Those who do not cooperate with treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Children's Sleep Habits Questionnaire (CSHQ);Autism Treatment Evaluation Checklist (ATEC);Behavior Rating Scale of Executive Function Preschool Version (BREIF-P); | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting EEG assessment;Image data; | — |
Countries
China
Contacts
Public ContactAizhen Qiu
Xuzhou Children's Hospital
Outcome results
None listed