Major depressive episode with suicidal ideation
Conditions
Interventions
Esketamine group:intravenous infusion of esketamine (0.5mg/kg)
MECT group:MECT
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
13 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged 13-85 years old,right-handed, inpatient treatment at the Affiliated Brain Hospital of Guangzhou Medical University; 2. Meet the diagnostic criteria for Major Depressive Disorder or bipolar disorder with Current or most recent episode depressed in the American Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM-IV); 3. HAMD-17 items = 17 points; 4. Patients with current suicidal ideation, and the scores of item 4 or item 5 of Beck Scale for Suicide Ideation (SSI) = 2; 5.Subjects with primary school education or above; 6.The subjects who understand the content of the study are willing to join the study and sign the written informed consent.
Exclusion criteria
Exclusion criteria: 1.Diagnosed with hypomanie episode or manic episode in 6 months, or the current YMRS >7 points; 2.Diagnosed with other mental disorders diagnosed by DSM-4, including schizophrenia, substance related disorder and addiction disorder, autism spectrum dsorder, intellectual disabilities(except anxiety disorder); 3.Patients with high suicide risk: had suicidal behavior (defined as self injuring behavior with intention to die) in the past six months, or the researchers judged that they had high suicide risk,or the answer of item 5 of a clinician-rated Columbia suicide severity rating scale (C-SSRS) ,whether they have suicidal ideation with specific plans and intentions,is yes; 4.Refractory hypertension, hypothyroidism or hyperthyroidism, vitamin B12 or folic acid deficiency, syphilis infection; 5.History of nervous system disease, like epilepsy, stroke, dementia, and brain trauma; 6.Suffering from major physical diseases such as heart, lungs, liver, and kidney, and cannot tolerate this study; 7.Past history of esketamine allergy; 8.Patients with angle-closure glaucoma. 9.Bladder irritation symptoms (frequency of urination, urgency of urination, pain in urination) that require clinical intervention; 10.Body mass index (BMI) 40kg/m2;, or
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Beck Scale for Suicide Ideation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montgomery-Asberg Depression Rating Scale;Hamilton Depression Scale;Hamilton Anxiety Scale;Snaim-Hamilton Pleasure scale;Dimensional Anhedonia Rating Scale;The Clinician Administered Dissociative States Scale; | — |
Countries
China
Contacts
Public ContactYuping Ning
The Affiliated Brain Hospital of Guangzhou Medical University
Outcome results
None listed