Ischemic cerebral stroke
Conditions
Interventions
TNK (0.25mg/kg, = 25mg, 5-10s intravenous injection):N/A
rt-PA (0.9mg/kg, = 90mg, initial 10% intravenous infusion, remaining 90% intravenous infusion = 1h):N/A
urokinase (1 million U to 1.5 million U, intravenous infusion for 30 minutes):N/A
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male or non pregnant female = 18 years old; 2. Time from onset to treatment ? 6 h; The time when symptoms begin is defined as the 'last time they appear normal'; 3. Independent neurological function before stroke (mRS 0-1); 4. Meet the conditions for intravenous thrombolysis, with a baseline NIHSS score of 4-26 points; 5.Written informed consent was provided by all participants or their representatives before their enrolment
Exclusion criteria
Exclusion criteria: 1. Any one of the following should be excluded and cannot be selected: 2. Severe neurological deficits (mRS = 2) prior to onset; 3. Have a history of intracranial hemorrhage; Intracranial tumors, arteriovenous malformations, or aneurysms; 4.Significant head injury or stroke, intracranial or spinal cord surgery within 3 months; 5. Major surgery or severe trauma within the past 30 days; 6. Digestive or urinary system bleeding in the last 30 days; 7. Myocardial infarction within the past three months; 8. Arterial puncture in non compressible area within the past 7 days; 9. Acute bleeding or active internal bleeding; 10. Platelet count1.6; 13. High blood pressure (systolic blood pressure>180mmHg or diastolic blood pressure>110mmHg); 14. Blood glucose concentration<50mg/dl (2.7mmol/L); 15. Pregnancy; 16. Residual neurological deficits after seizures; 17. Allergies to research drugs; 18. Those with severe diseases of other organs and an expected life of no more than 6 months; 19. Other situations that the researcher deems unsuitable for participation in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of patients with favourable functional outcomes (defined as an mRS score of 0–2 at 90 days);;Analysis of time delay of pre-hospital of intravenous thrombolysis in acute ischemic stroke; | — |
Secondary
| Measure | Time frame |
|---|---|
| The proportion of patients with a substantial neurological improvement on the NIHSS (defined as a decrease of at least 4 points at 24 h) or the score of the NIHSS score decreased compared to the baseline;The ordered distribution of mRS score at 90 days;90-day mortality rate;The time of hospital stay and intensive care unit time, and hospitalization costs; | — |
Countries
PR China
Contacts
Public ContactSuiqiang Zhu
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed