Knee arthritis and total knee arthroplasty
Conditions
Interventions
AH group:THA is performed using a standard anterior median incision and a medial parapatellar approach. A tourniquet is applied for 10 minutes at the time of skin incision and during cementation. Afte
TXA group:THA is performed using a standard anterior median incision and a medial parapatellar approach. A tourniquet is applied for 10 minutes at the time of skin incision and during cementation. Aft
AH + TXA group:THA is performed using a standard anterior median incision and a medial parapatellar approach. A tourniquet was applied for 10 minutes at the time of skin incision and during cementatio
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18~80 years; 2. American Society of Anesthesiologists (ASA) functional status of I-III; 3. Underwent TKA for primary end-stage knee osteoarthritis; 4. Consented to participate in the trial.
Exclusion criteria
Exclusion criteria: 1. Diagnoses other than primary osteoarthritis or preoperative anemia; 2. Allergic to tranexamic acid (TXA) or related drugs; 3. Anticoagulant use 7-14 days prior to surgery; 4. History of hematological disorders, venous thrombosis, or BMI>35 kg/m^2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total blood loss;Intraoperative blood loss;Hidden blood loss;Hemoglobin level;Hematocrit level;Maximum hemoglobin change;Number and volume of blood transfusion;Incidence rate of thrombosis;Wound-related complications;IV fluid amount;Number of anemia;Incidence of severe adverse events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Platelet count;Activated partial thromboplastin time;Prothrombin time;Erythrocyte sedimentation rate;C-reactive protein;Interleukin-6 level;D-dimer level;Fibrinogen levels;Knee circumference;Knee mobility;HSS scores;VAS;Stride speed;Live and kidney functions (blood biochemistry);Incidence of other adverse reactions; | — |
Countries
China
Contacts
Public ContactYi Zeng
West China Hospital, Sichuan University
Outcome results
None listed