hepatitis B virus
Conditions
Interventions
NAs-treated group (adding on PEG-IFN treatment):N/A
naive group (PEG-IFN treatment):N/A
Sponsors
General Hospital of Eastern Theater Command
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: positive-HBsAg last for more than 6 months prior to enrollment; HBV DNA=10000 IU/ml; HBsAg=5000 IU/ml(Architect HBsAg assay), especially HBsAg=1500 IU/ml; HBeAg=100 S/CO or undetected; alanine aminotransferase (ALT)=5 upper limitation of normal (ULN); age from 10 to 60 years; males and females all can be accepted; no cirrhosis except compensated cirrhosis (Child A).
Exclusion criteria
Exclusion criteria: autoimmune diseases; severe metabolic diseases; history of severe psychiatric disease, especially depression; severe complications in any organ; pregnant during treatment or will be pregnant in 6 months after treatment; lactating women; evidence of carcinoma; and any other situations that cant use PEG-IFN according to the illustration; treatment duration didnt reach 48 weeks or didn’t do tests at observed time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TCR;HBsAg; | — |
Countries
China
Contacts
Public ContactHao Kunyan
General Hospital of Eastern Theater Command
Outcome results
None listed