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Study on the pathogenesis of cerebral microinfarction and the mechanism of cognitive dysfunction based on multimodal MRI

Study on the pathogenesis of cerebral microinfarction and the mechanism of cognitive dysfunction based on multimodal MRI

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300071649
Enrollment
Unknown
Registered
2023-05-22
Start date
2023-05-22
Completion date
Unknown
Last updated
2023-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral microinfarcts

Interventions

Case series:none

Sponsors

Guihang Guiyang Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients with cerebrovascular injury in the Department of Neurology, Guihang Guiyang Hospital, patients had to show at least one of the following forms of vascular brain injury on MRI,?white matter hyperintensities (WMH) with a Fazekas scale grade =2,?Fazekas scale grade 1 and an increased vascular risk defined as the presence of =2 vascular risk factors (hypertension,hypercholesterolemia, diabetes mellitus, obesity, current smoking, or a reported history of a vascular event other than stroke);?=1 lacunar infarct(s); ?=1 nonlacunar infarct(s); ?=1 cerebral microbleed(s);?=1 intracerebral hemorrhag; 2.Aged = 50 years, = 80 years; 3. All underwent head MRI examination(3D_T1,3D_T2,3D_T2-FLAIR,3D_DIR,DWI,SWI,ASL,QSM); 4.Sign the informed consent form. The above criteria must be met at the same time.

Exclusion criteria

Exclusion criteria: 1. Poor image quality that unable to evaluate and analyze; 2. Other brain diseases: such as tumors, trauma, metabolism/poisoning, infections, etc; 3. Depression or other mental illnesses. If one of the above items is met, it will be exclud

Design outcomes

Primary

MeasureTime frame
Brain MRI parameters;

Secondary

MeasureTime frame
Neuropsychological assessment;Demographic date;

Countries

China

Contacts

Public ContactHe jianfeng

Guihang Guiyang Hospital

hejf301@163.com+86 173 1923 5970

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026