Liver cancer
Conditions
Interventions
placebo control group:Patients in the control group will receive equivalent volumes of saline, and connect the patient-controlled intravenous analgesia pump after surgery.
lidocaine + S-ketamine group:Patients will be administered an intravenous bolus injection of 0.25 mg/kg S-ketamine and 1.5 mg/kg of lidocaine (calculated using the patients ideal body weight and given
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years; 2. Scheduled for elective hepatectomy; 3. ASA grade I-III.
Exclusion criteria
Exclusion criteria: 1. Patients with a tube into the ICU after surgery and no extubation plan within 6 hours after surgery; 2. Weight less than 40 kg or larger than 100 kg; 3. With defects in the cardiac conduction system (second- or third-degree block) or cardiac insufficiency (LVEF < 50%); 4. With severe hepatic insufficiency (ALT, AST, bilirubin more than 2.5 times higher than normal), renal insufficiency (creatinine clearance rate < 60 mL/min); 5. Hypersensitivity to the test drug; 6. Long-term opioid abuse; 7. Inability to communicate; 8. Combined with serious physical diseases, such as uncontrolled hypertension, coronary heart disease, intracranial vascular malformations, asthma attacks, etc.; 9. Those with a history of epilepsy and a history of manic episodes; 10. Pregnant and lactating women; 11. With glaucoma; 12. Preoperative cognitive dysfunction, bipolar disorder, or other mental diseases and mental retardation; 13. Primary liver cancer combined with malignant tumors of other organs (such as lung, kidney, intestine, etc.), preoperative clinical symptoms or imaging examination indicate that there has been distant metastasis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| numerical rating scale (NRS) scores of movement-evoked pain at postoperative 24 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS scores of movement-evoked pain at postoperative 48 and 72 hours;NRS scores of pain at rest at 48 and 72 hours postoperatively;the incidence of moderate-to-severe movement-evoked pain at 24, 48 and 72 hours postoperatively;The incidence of moderate-to-severe pain at rest at 24, 48 and 72 hours postoperatively;the cumulative morphine consumption at 24, 48 and 72 hours postoperatively;Time of Bowel function recovery;the incidence of postoperative nausea and vomiting during the first 72 hours postoperatively (any nausea or vomiting);the incidence of a composite of postoperative pulmonary complications during hospitalisation;Length of hospital stay;Quality of Recovery Scale Score at 24, 48 and 72 hours after surgery; | — |
Countries
China
Contacts
Public ContactYan Xu
West China Hospital, Sichuan University
Outcome results
None listed