Rheumatoid arthritis, ankylosing spondylitis
Conditions
Interventions
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Healthy volunteers: 1. A history of diagnosis and treatment of rheumatic immune diseases (including but not limited to ankylosing spondylitis and rheumatoid arthritis) should be excluded for healthy volunteers. 2. Age 18-85, gender unlimited. 3. Informed consent and sign the informed consent. Rheumatoid arthritis and ankylosing spondylitis patients: 1. Confirmed clinical diagnosis of rheumatoid arthritis (meeting the EULAR/ACR2010 diagnostic criteria) or ankylosing spondylitis (meeting the 1984 New York criteria or the 2009 ASAS diagnostic criteria for axial spinal arthritis). 2. Age 18-85, gender unlimited. 3. Informed and consenting.
Exclusion criteria
Exclusion criteria: (1) Received intra-articular, intramuscular or intravenous corticosteroids, including adrenotropic hormone, or other medications within 4 weeks; (2) Overlap with other autoimmune diseases such as gouty arthritis, systemic lupus erythematosus, etc.; (3) Patients who had previously used fusion protein biologics (including Esep, Qiangke, Amberol, Enli, etc.) before the operation stopped < 4 weeks, patients who had used monoclonal antibody biologics (including adalimumab, Infliximab, tozizumab, etc.) before the operation stopped < 4 weeks (4) Patients with serious diseases of vital organs such as cardiovascular, brain, liver, lung, kidney and hematopoietic system, acute and chronic infectious diseases, malignant tumors, and psychiatric diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression of pyroptosis-related genes in CD8+T cells and neutrophils;Serum bone destruction related index and disease activity evaluation index; | — |
Secondary
| Measure | Time frame |
|---|---|
| DAS28;BASDAI; | — |
Countries
China
Contacts
Public ContactChen Xiumin
Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed