recurrent implantation failure
Conditions
Interventions
PGT-A group:blastocyst morphologic score, blastocyst biopsy, NGS sequencing, single thawed blastocyst transfer
IVF group:blastocyst morphologic score, single thawed blastocyst transfer
Sponsors
Center for Reproductive Medicine, Shandong University
Eligibility
Sex/Gender
Female
Age
20 Years to 38 Years
Inclusion criteria
Inclusion criteria: 1. Infertile women with a history of RIF, RIF refers to failure to achieve a clinical pregnancy after one of the following conditions with all embryos transferred being of good quality: (1) 3 or more embryo transfer cycles; (2) 2 embryo transfer cycles where no less than three embryos were transferred cumulatively; 2. Women under the age of 38 years at the time of informed consent; 3. Women with at least 1 good-quality blastocysts on day 5 or day 6 of embryo culture.
Exclusion criteria
Exclusion criteria: 1. Women with a uterine cavity abnormality, such as a uterine congenital malformation (uterus unicornate, bicornate, or duplex); untreated uterine septum, submucous myoma, multiple endometrial polyp(s); or with a history of severe intrauterine adhesions; with untreated hydrosalpinx; with thin endometrium (= 2 previous miscarriages; 4. Previous implantation failure occurred after transfer of euploid embryos following PGT-A; 5. Women who are indicated and planned to undergo PGT-M or PGT-SR; 6. Women who use donated oocytes or sperm to achieve pregnancy; 7. Women with medical contraindications to assisted reproductive technology and/or pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate after initial transfer; | — |
Secondary
| Measure | Time frame |
|---|---|
| good birth outcome;biochemical pregnancy rate;clinical pregnancy rate;ongoing pregnancy rate;rate of biochemical pregnancy loss;rate of clinical pregnancy loss;rate of multiple pregnancy;birth weight;risk of maternal complications;risk of neonatal complications; | — |
Countries
China
Contacts
Public ContactChen Zi-Jiang, Yan Junhao
Center for Reproductive Medicine, Shandong University
Outcome results
None listed