adults with major depressive disorders and/or ADHD
Conditions
Interventions
Sponsors
Peking University Sixth Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1) Be 18-45 years of age; 2) Diagnosed by an attending psychiatrist or higher, meeting the DSM-5 diagnostic criteria for adult MDD (current or previous) and/or ADHD (current); 3) The presence of "psychomotor retardation" or "diminished ability to think or concentrate or indecision" in the DSM-5 diagnostic criteria for patients with MDD; (4) HAMD-24 score = 20; (5) Unadjusted medication dose in the last 4 weeks.
Exclusion criteria
Exclusion criteria: 1) Having a mental disorder other than MDD, ADHD, or anxiety spectrum disorder; 2) Having a history of neurological disorders such as epilepsy, history of traumatic brain injury, or serious physical illness; 3) Being pregnant or breastfeeding; 4) Severe suicidal ideation (score =3 on the suicide item of the HAM-D) and the recent presence of self-injurious behavior; 5) Those with an intelligence level below the normal range, i.e., a total IQ score of less than 90 on the Wechsler Intelligence Test; 6) A frontal skin condition that may impede light penetration, such as a tattoo or birthmark; 7) Receiving photosensitizing medication within 14 days 8) Having an implant in the head, such as an endovascular stent placement, to prevent possible dislocation associated with vasodilation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy and response time for N-back tasks;Resting state and N-back task fNIRS brain activation and functional connectivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| CPT-IP signal detection index;HAMD-24 Score; | — |
Countries
China
Contacts
Public ContactQianQiujin
Peking University Sixth Hospital
Outcome results
None listed