Maintenance hemodialysis patients
Conditions
Interventions
Nafamostat Mesilate:Flush the circuit with 1000ml of normal saline. Dissolve 20mg of Nafamostat Mesilate in at least 2 ml of 5% glucose and add it to 500ml of normal saline to pre-fill the circuit and
Non-anticoagulant group:Flush the circuit with 1000ml of normal saline prior to use. During dialysis, clamp the arterial end of the extracorporeal circuit every 60 minutes and flush the circuit and fi
Sponsors
Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1)Patients with end-stage renal disease and receiving maintenance hemodialysis; 2)Aged 18 years or older; 3)Undergoing hemodialysis 2-3 times per week, with each session lasting 4 hours; 4)Treatment modality is hemodialysis with a dialysate flow rate of up to 500ml/min and a blood flow rate of 3.5-4ml/min.kg; 5)Presence of significant bleeding or high risk of bleeding (defined as within 3 days after active bleeding, within 3 days after invasive procedures or surgeries, or within 7 days before scheduled surgeries or invasive procedures); 6)Signed informed consent.
Exclusion criteria
Exclusion criteria: 1)Patients with hematological diseases (such as hemophilia, allergic purpura, etc.); 2)Patients who have used anticoagulants, antiplatelet drugs or other drugs affecting coagulation function within the past week; 3)Patients with pulmonary bleeding diseases, those scheduled for bronchoscopy, or those who have undergone bronchoscopy; 4)Patients with a pre-dialysis potassium level higher than 6.5mmol/L; 5)Patients with severe allergies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Extracorporeal circuit occlusion event; | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute complication; | — |
Countries
China
Contacts
Public ContactFeng Zhonglin
Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University
Outcome results
None listed