none
Conditions
Interventions
Case series:N/A
Sponsors
Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age 18~85 years old. 2. Patients who plan to undergo elective non-cardiac, non-cranial surgery under general anesthesia with an expected operative timing > 60 minutes. 3. ASA ?~?. No severe systemic diseases or severe anemia, with normal coagulation function. Cardiopulmonary, hepatic and renal functions and biochemical indicators are in the normal compensatory range. 4. Consent to participate and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. BMI > 32 or < 17.5 2. severely impaired heart function (unable to cope with daily activities) 3. abnormal coagulation function, liver and kidney function 4. severe pulmonary dysfunction (including pneumonia, pulmonary atelectasis, pleural effusion, acute lung injury, ARDS) 5. severe circulatory instability (severe coronary artery disease, unstable angina, left ventricular ejection fraction <30%, sick sinus syndrome, severe sinus bradycardia <50 bpm, second-degree or worse atrioventricular block) 6. pregnancy 7. neurological dysfunction 8. predictable difficult airway 9. patients with a history of long-term analgesic or sedative medication 10. hypovolemia 11. abnormal body temperature 12. known allergy or intolerance to the drug being tried 13. refusal to participate in the study 14. participation in other clinical trials within 30 days prior to randomization
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| plasma concentration of ciprofol in arterial; | — |
Countries
China
Contacts
Public ContactLiqun Yang
Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed