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The neural mechanism of transcranial direct current stimulation targeting premotor cortex for motor dysfunction of upper extremity with spasticity in stroke

The neural mechanism of transcranial direct current stimulation targeting premotor cortex for motor dysfunction of upper extremity with spasticity in stroke

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300071574
Enrollment
Unknown
Registered
2023-05-18
Start date
2023-06-01
Completion date
Unknown
Last updated
2023-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

Experimental group:tDCS in the PMC region true stimulation
Control group:tDCS sham stimulation in the PMC region

Sponsors

The First Affiliated Hospital of Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) the first occurrence of stroke as confirmed by computed tomography or magnetic resonance imaging which resulted in unilateral hemiparesis (2) stroke onset =6 months, age: 30-75 years old (3) The muscle strength grade of the affected upper limb is = 3the passive range of wrist joint was between -20° palmar flexion and 30° dorsiflexion (4) the MAS score for the radiocarpal joint =1.

Exclusion criteria

Exclusion criteria: (1) medically unstable (2) receiving muscle relaxant or anti-spastic medication (3)infraction at the cerebellum or brain stem region (4) upper limb fracture or non-muscle spasm related restriction of joint movement (5) Patients with contraindications to tDCS or other conditions that could not cooperate with this experiment.

Design outcomes

Primary

MeasureTime frame
Cortical deoxyhemoglobin/oxygenated hemoglobin concentration;surface EMG root mean square value;

Secondary

MeasureTime frame
Clinical scales MAS and FMA;muscle stiffness;

Countries

China

Contacts

Public ContactLeng yan

The First Affiliated Hospital of Sun Yat-sen University

lengyan@mail2.sysu.edu.cn+86 159 2046 6205

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026