Mild Congitive Impairment
Conditions
Interventions
MCI Experimental group:Photoacoustic stimulation
MCI Control group:Sham stimulation
Healthy Experimental group:Photoacoustic stimulation
Healthy Control group:Sham stimulation
Sponsors
The 2nd Affiliated Hospital of Zhejiang University, School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Patients: 1. Aged 50-80 years old 2. Diagnosed with MCI according to Petersen diagnostic criteria 3. Minimum Mental State Examination (MMSE) score between 17 and 22 4. Geriatric Depression Scale Brief (GDS-15) GDS = 5 5. No visual or auditory pathology to allow scale monitoring 6. = 5 years of education and able to complete normal communication 7. If taking medication, ensure that it is stable for at least 3 months 8. Understand the procedure and protocol and sign a written informed consent form Healthy people: 1. Aged 18-85 years old 2. No visual or auditory abnormalities, capable of completing scale monitoring 3. = 5 years of education and able to complete normal communication 4. Understand the procedure and protocol and sign a written informed consent form
Exclusion criteria
Exclusion criteria: 1. Left-handed 2. People who cannot tolerate or have contraindications for MRI scanning 3. Individuals with severe eye diseases such as glaucoma and cataracts 4. Patients with mental/neurological disorders such as mania and epilepsy 5. Participation in other trials within the last 3 months (including memory clinics, online cognitive games, etc.) 6. Have received other internal medication for the condition prior to consultation: within 3 months of screening, have received the following medications: memantine, stilbestrol, donepezil, galantamine carbamate or other experimental medications 7. If the answer to any of the above is "yes", the subject will not be allowed to enter the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Magnetic resonance imaging scanning (MRI);Mini-mental state examination (MMSE); | — |
Secondary
| Measure | Time frame |
|---|---|
| Pittsburgh sleep quality index (PSQI);Electroencephalogram (EEG);Alzheimer’s Disease Assessment Scale – Cognitive Subscale (ADAS-Cog);Geriatric Depression Scale (GDS);Activity of Daily Living Scale (ADL); | — |
Countries
China
Contacts
Public ContactZhang Minming
The 2nd Affiliated Hospital of Zhejiang University, School of Medicine
Outcome results
None listed