postoperative delirium
Conditions
Interventions
ACEI/ARB continuous group:Continue to take ACEI/ARB during perioperative period
ACEI/ARB interrupt group:ACEI/ ARBs were discontinued from 1 day before surgery to 1 day after surgery
Sponsors
Wenzhou Hospital of Integrated Chinese and Western Medicine
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) =65 years old; 2) ASA Grade I-III; 3) Receiving conventional angiotensin-converting enzyme inhibitors or angiotensin-receptor inhibitors for hypertension for =2 weeks; 4) Except for extremity fracture, joint correction, abdominal, gynecological and urological elective surgery, time >1h.
Exclusion criteria
Exclusion criteria: 1) Taking angiotensin converting enzyme inhibitors or angiotensin receptor inhibitors at night and intermittently; 2) Taking other antihypertensive drugs simultaneously; 3) Baseline systolic blood pressure =180 mmHg, diastolic blood pressure =110 mmHg, mean blood pressure =65 mmHg; 3) Dementia, Parkinson's disease and MMSE<10 before operation; 4) History of cardiovascular and cerebrovascular diseases, intracranial or spinal surgery in the past 1 year; 5) serious heart and lung disease; 6) Chronic kidney disease = stage 4, on dialysis, creatinine =150µmol/L, eGFR< 15ml /min/ 1.73m2; 7) ChildPugh grade of liver dysfunction =B; 8)Diagnostic invasive surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Delirium subtype, severity, duration;Vascular paraplegic shock;Incidence of hypertension;Use of intraoperative fluids and vasopressors;Adverse events of heart, brain and kidney;Perioperative drugs; | — |
Countries
China
Contacts
Public ContactYizheng Li
Wenzhou Hospital of Integrated Chinese and Western Medicine
Outcome results
None listed