chronic cough(gastroesophageal reflux-induced cough)
Conditions
Interventions
vonoprazan group:vonoprazan 20mg,bid
omeprazol group:omeprazole 20mg,bid
Sponsors
Tongji Hospital, Tongji University School of Medicine, Shanghai, China
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: ?18 years = age = 70 years; ?the diagnosis of GERC was in accordance with the Chinese Guidelines for the Diagnosis and Treatment of Cough in 2021; ?No contraindications to P-CAB and/or PPIs treatment; ?Able to clearly understand the purpose of the study, be willing and able to comply with the requirements to complete the study, and sign the informed consent.
Exclusion criteria
Exclusion criteria: ?Pregnant or lactating women; ?Smoking within the past 2 years; ?Those who have used PPIs within 2 weeks; ?History of respiratory tract infection within 8 weeks; ?A history of potassium competitive acid blockers and/or proton pump inhibitors for contraindications or allergies; ?Mental illness or other reasons for the inability to cooperate with treatment; ?Have serious heart, liver, kidney and other important organs and blood, endocrine system lesions; ?Other conditions were deemed by the investigator to be unsuitable for participation in the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cough symptom scores;LCQ?Gerd Q and HAR Q scores;capsaicin cough sensitivity ; | — |
Secondary
| Measure | Time frame |
|---|---|
| MII-PH; | — |
Countries
China
Contacts
Public ContactYu Li/ Xu xianghuai
Tongji Hospital, Tongji University School of Medicine, Shanghai, China
Outcome results
None listed