Parkinson's disease
Conditions
Interventions
Control group:The anode was placed on M1 of the dominant hemisphere, and the cathode was placed on the contralateral supraorbital fissure. The electrode was placed for 20min, and 2mA stimulation was g
Primary motor stratum(M1):The anode was placed on the dominant hemisphere M1, and the cathode was placed on the contralateral supraorbital fissure. The stimulation intensity was 2mA and the duration o
Left dorsolateral prefrontal cortex group:The anode was placed on the dominant hemisphere DLPFC, and the cathode was placed on the contralateral superior orbital fissure. The stimulation intensity was
Sponsors
The First Affiliated Hospital of Xinxiang Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ? All of them are in line with the diagnostic criteria for PD introduced in the 2020 Chinese Guidelines for the Treatment of Parkinson's Disease (Fourth Edition) [6]; ? 45-75 years old; ? The modified Hoehn-Yahr grade was 1-3 during the drug administration, and the drug treatment regimen did not change during the study. (4) The score of simple mental state examination (MMSE) should not be lower than the requirements (MMSE=24 points for high school education or above, =18 points for elementary and middle school education, =13 points for illiteracy); ? Patients were aware of this study and signed written informed consent.
Exclusion criteria
Exclusion criteria: ? Severe neurological diseases (mRS Score =3 after stroke and traumatic brain injury), mental illness and severe cognitive impairment; (2) Suffering from unstable cardiovascular disease or other uncontrolled chronic diseases; ? Motor function is affected by fracture or other skeletal muscle injury in the last 1 year; ? PD has been treated with deep brain stimulation (DBS); (5) Contraindications with tDCS, such as intracranial metal implants, epilepsy, and electronic devices implanted in the body.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MDS-UPDRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| FOGQ;Timed up and go test,TUGT; | — |
Countries
China
Contacts
Public ContactCongcong Wang
The First Affiliated Hospital of Xinxiang Medical University
Outcome results
None listed