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Effects of N-acetylcysteine on ROS/NLRP3 mediated pyroptosis in AECOPD patients

Effects of N-acetylcysteine on ROS/NLRP3 mediated pyroptosis in AECOPD patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300071503
Enrollment
Unknown
Registered
2023-05-17
Start date
2023-05-07
Completion date
Unknown
Last updated
2023-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic obstructive pulmonary disease

Interventions

healthy control:none
AECOPD:normal treatment
NAC:normal treatment+NAC

Sponsors

the First People's Hospital of Lianyungang City
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: ? Patients with AECOPD admitted to ICU need invasive mechanical ventilation;? Age > 18 years old;3?18=BMI=24 Kg/?? Informed consent.

Exclusion criteria

Exclusion criteria: ?severe coagulation disorder before;? multiple organ failure;? Pregnancy, terminal stage of tumor.

Design outcomes

Primary

MeasureTime frame
ROS;NLRP3;ASC;cleaved-caspase1;GSDMD-N;IL-18;cleaved- IL -1ß;—

Countries

China

Contacts

Public ContactKang Xiuwen

the First People's Hospital of Lianyungang City

mafei8922@163.com+86 189 6132 2205

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026