COVID-19 diseases
Conditions
Interventions
test team:Basic western medicine treatment+traditional Chinese medicine intervention treatment(Huashi Paidu Yishen recipe/Hushen Jiedu recipe)
Sponsors
Ningbo Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. The diagnosis of western medicine conforms to novel coronavirus's criteria for diagnosis and severe typing of infection, CKD's criteria for diagnosis and staging CKD stage 4-5 (GFR < 30ml/min/1.73m2) and dialysis patients. 2. TCM syndrome differentiation conforms to the syndrome of epidemic toxin closing lung or yang deficiency and epidemic toxin invading lung. 3. The age is between 18 and 85; 4. The subjects agreed and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with serious diseases of important organs, such as moderate and severe liver dysfunction (transaminase is 3 times higher than normal), malignant tumor, severe anemia (HB is less than 60g/L), and cardiovascular and cerebrovascular stent implantation in recent 3 months; 2. Those who are taking immunosuppressants or other antiviral drugs and cannot stop using them; 3. Those who are allergic to the known components of the test drug or are severely allergic. 4. Pregnant or lactating women 5. Participated in other clinical trials 3 months before screening. 6. Other circumstances in which the researcher judges that the compliance is poor or that it is not suitable to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time interval and proportion from random to clinical improvement (clinical symptoms include respiratory rate, skin oxygen, oxygenation index PaO2/FiO2, CT imaging changes, subject to the improvement time of the last index);Improvement time of chest CT and the proportion of patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| The proportion of subjects whose disease progressed to critical condition during the observation period of 28 days after randomization.;All-cause mortality of the subjects in the observation period of 28 days after randomization;Time interval from random to discharge;The proportion of patients whose TCM syndrome score decreased by =30% during the observation period of 14 days after randomization;Inflammation index;Tcm syndrome curative effect score; | — |
Countries
China
Contacts
Public ContactXudong Cai
Ningbo Hospital of Traditional Chinese Medicine
Outcome results
None listed