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Sequential method for determining ED50 of nalbuphine for intraoperative analgesia in elderly patients undergoing percutaneous kyphoplasty

Sequential method for determining ED50 of nalbuphine for intraoperative analgesia in elderly patients undergoing percutaneous kyphoplasty

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300071476
Enrollment
Unknown
Registered
2023-05-16
Start date
2023-05-16
Completion date
Unknown
Last updated
2023-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative pain

Interventions

Group of spinal compression fracture:nalbuphine for intraoperative analgesia

Sponsors

The 964th Hospital of the People's Liberation Army Joint Service Support Force
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Aged 60-85 years; 2. ASA score I - III; 3. Imaging diagnosis of spinal compression fracture 4. Voluntary subjects and signed informed consent

Exclusion criteria

Exclusion criteria: 1. History of mental illness or being treated with psychotropic drugs; 2. Non-fracture loose spinal fractures caused by tuberculosis and tumor. 3. Those who take sedative and analgesic drugs for a long time or before operation; 4. Patients with severe cardiovascular and cerebrovascular system and chronic respiratory insufficiency (arterial oxygen saturation < 95%); 5. Those who have been allergic to nalbuphine hydrochloride opioids and lidocaine amide local anesthetics in the past; 6. Failure to cooperate with researchers for any reason; 7. There was cognitive dysfunction before operation (the score of simple mental state examination was <=23).

Design outcomes

Primary

MeasureTime frame
Median effective dose;Dosage of Nalbuphine;NRS score of intraoperative pain;

Secondary

MeasureTime frame
adverse effect;Patients' satisfaction score;doctors' satisfaction score;

Countries

China

Contacts

Public ContactPeng Zhao

The 964th Hospital of the People's Liberation Army Joint Service Support Force

66949366@qq.com+86 132 7266 7982

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026