Perioperative neurocognitive disorders
Conditions
Interventions
POD vs No-POD:None
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for abdominal surgery under general anesthesia; 2. Age >= 60 years; 3. ASA classification I - III; 4. Individuals who have signed the informed consent form prior to surgery.
Exclusion criteria
Exclusion criteria: 1. Patients for emergency surgery; 2. Documented history of severe heart, lung, liver and kidney dysfunction; 3. Documented history of neuropsychiatric diseases such as anxiety, depression, dementia, stroke, epilepsy, Parkinson's disease and AD before operation; 4. Patients with cognitive impairment assessed by MMSE; 5. Patients with serious auditory or visual dysfunction; 6. Alcohol or drug addicts; 7. Individuals who do not cooperate or with communication difficulties.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The occurrence of POD (Postoperative Delirium);The occurrence of POCD (Postoperative cognitive dysfunction); | — |
Secondary
| Measure | Time frame |
|---|---|
| Whole blood transcriptome;Mitochondrial metabolism of platelet in peripheral blood;Mitochondrial metabolism of monocytes in peripheral blood;Inflammatory phenotype of monocytes in peripheral blood;Glucose metabolism and its downstream pathway of monocytes in peripheral blood;Adverse events; | — |
Countries
China
Contacts
Public ContactYan Yang
Nanjing Drum Tower Hospital
Outcome results
None listed