Analgesia after general anesthesia
Conditions
Interventions
HN group:Hydromorphone 0.7ug/kg/ml+narbuphine7ug/kg/ml
H group:Hydromorphone 1.4 ug/kg/ml
Sponsors
Shengjing Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. ASA Grade I or II 2. Age 18-65, BMI 18-35 kg/m2 3. Laparoscopic abdominal surgery (hepatobiliary surgery, gastroduodenectomy, splenectomy, pancreatectomy, nephrectomy, colorectal resection)
Exclusion criteria
Exclusion criteria: 1. Merge pain related diseases unrelated to surgery, such as herpes zoster, trigeminal neuralgia, etc 2. Individuals with a previous history of opioid allergy and allergies to hydromorphone, hydromorphone salts, and nabrphine; Drug abusers; 3. Previous history of nausea and vomiting after general anesthesia and abnormal anesthesia recovery; 4. Preoperative liver and kidney function abnormalities (alanine transaminase, glutamic oxaloacetic transaminase, creatinine, urea nitrogen more than twice the normal value); 5. Those who are unable to communicate normally with others, cannot understand NRS scores, and cannot use pain pumps; 6. Use sedatives, antiemetics, and antipruritic drugs within 24 hours before surgery; 7. Long term use of analgesics or antipsychotics (including opioids, non steroidal anti-inflammatory drugs, sedatives, antidepressants, etc.) due to chronic pain or mental or nervous system disease 8. Patients with severe or acute asthma; 9. Change in surgical method and transfer to intensive care unit (ICU) after surgery; 10. There is a risk of gastrointestinal obstruction, especially in patients with paralytic intestinal obstruction. Patients with fertility requirements within one year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS pain score at each time point immediately after operation, entering the recovery room, 2h, 6h, 12h, 24h and 48h after operation;The overall benefit of analgesia scores at the time points immediately after operation, entering the recovery room, 2h, 6h, 12h, 24h and 48h after operation is OBAS.;Cognitive function evaluation and MMSE score of patients 1 and 2days after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of analgesic pump compressions;Total drug consumption and total self-administered analgesic medication;Intraoperative blood loss and fluid administration;Whether lung infection; | — |
Countries
China
Contacts
Public ContactYang Fan
Shengjing Hospital of China Medical University
Outcome results
None listed