hypertension
Conditions
Interventions
sarcopenia group:Azisartan 20mg qd
severe sarcopenia group:Azisartan 20mg qd
Sponsors
Sir Run Run Hospital, Nanjing Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 95 Years
Inclusion criteria
Inclusion criteria: (1) Age =60 years old (2) Patients diagnosed with grade 1 and grade 2 hypertension for the first time according to the Chinese Guidelines for the Management of Hypertension in the Elderly 2019 (3) Patients with sarcopenia diagnosed in accordance with the Expert Consensus on the Diagnosis and Treatment of sarcopenia among the Elderly in China 2021. (1) The skeletal muscle mass index of limbs was determined by BIA method: male < 7.0kg/m2, female < 5.7kg/m2; (2) Grip strength: male < 28kg, female < 18kg; (3) Indicators of muscle function decline: 6-meter pace < 1.0 m/s. With the above (1)+(2) or (1)+(3) can be diagnosed as sarcopenia, with (1)+(2)+(3) is severe sarcopenia
Exclusion criteria
Exclusion criteria: (1) Patients with hypertension level 3 (2) Those who are allergic to or have contraindications to ARB drugs (3) diseases of the nervous system or bone and joint and unable to complete the assigned actions (4) Severe cardiopulmonary insufficiency (unable to carry out normal daily activities; The New York Heart Function rating is III, IV, or cannot tolerate a 6 meter walking test) (5) Severe renal insufficiency (creatinine clearance < 60ml/min), severe liver damage (aminotransferase increase more than 2 times) (6) Patients with malignant tumor diseases (7) Patients with mental disorders and senile dementia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour ambulatory blood pressure;office Blood Pressure;Skeletal muscle mass;grip;6 meter pace;Short Physical Performance Battery; | — |
Countries
China
Contacts
Public Contactgaowei
Sir Run Run Hospital, Nanjing Medical University
Outcome results
None listed