ß-thalassemia major
Conditions
Interventions
Trail group:None
Sponsors
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Genetically confirmed ß-TM. 2. HSCT was performed between January 2008 and December 2022 in the hematopoietic stem cell transplantation specialty of children's Medical Center in Sun Yat-sen Memorial Hospital. 3. Age at HSCT was < 18 years old. 4. Fasting insulin and fasting glucose were assessed after HSCT in Sun Yat-sen Memorial Hospital.
Exclusion criteria
Exclusion criteria: 1.Dependent on RBC transfusion at time of assessment. 2.Insulin resistance, impaired fasting glucose, impaired glucose tolerance or diabetes had been confirmed before HSCT. 3.Previous glucocorticoid use within 3 months before assessment and children having received treatment with drugs affecting glucose metabolism at the time of assessment. 4.Children had acute infectious disease or active GVHD at the time of assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fasting insulin;fasting plasma glucose;serum ferritin; | — |
Secondary
| Measure | Time frame |
|---|---|
| OGTT test;insulin release test;heart T2*;liver T2*;pancreas T2*; | — |
Countries
China
Contacts
Public ContactLiang Liyang
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Outcome results
None listed