Breast cancer
Conditions
Interventions
Group R:Serratus anterior plane block (ropivacaine)
Group RD0.5:Serratus anterior plane block (Ropivacaine and dexmedetomidine 0.5ug/kg)
RD1.0:Serratus anterior plane block (Ropivacaine and dexmedetomidine1.0ug/kg)
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
Female
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. BMI 18-28kg/m2. 2. Patients who are scheduled to undergo modified radical mastectomy. 3. ASA I-III. 4. The patient or an authorized relative signed the informed consent. 5. Have completed the auxiliary examination of admission.
Exclusion criteria
Exclusion criteria: 1. There are contraindications for nerve block, such as coagulation dysfunction, infection at the puncture site, and refusal of nerve block by the patient. 2. Preoperative concomitant cognitive dysfunction. 3. A variety of reasons, such as visual impairment, hearing impairment, mental illness, etc., may not be sufficient to complete the postoperative assessment. 4. Present with sick sinus syndrome and/or basal heart rate less than 50 beats per minute. 5. History of allergy to dexmedetomidine and ropivacaine. 6. Complicated with serious cardiopulmonary dysfunction, liver and kidney dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve of numerical scores of pain intensity within 24 hours.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The time of first analgesic relief;Morphine analgesic remediation consumption in PCA;Postoperative sedation level;Incidence of perioperative bradycardia and hypotension.;Incidence of moderate or higher pain within 24 hours after surgery and the highest value of the NRS;Adverse ;Preoperative and postoperative 24 hours of QoR-15 scale scores.; | — |
Countries
china
Contacts
Public ContactKejian Shi
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed