diabetic retinopathy
Conditions
Interventions
control group:PPV+P+I
intervention group:PPV+P+I+posterior capsulotomy
Sponsors
Tianjin Medical University Eye Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) Age: >=18 years old; 2) PPV with cataract surgery is required for patients diagnosed with proliferative diabetic retinopathy (stage IV to VI diabetic retinopathy according to the International Classification of Diabetic retinopathy) and cataract; 3) Patients with indications of surgery; 4) At least part of the cornea is transparent (or the central area of the cornea is transparent) to ensure fundus examination, visual function examination and OCT examination after vitrectomy; 5) Able and willing to sign informed consent
Exclusion criteria
Exclusion criteria: 1) Unwilling or unable to agree to participate in the study, unable to participate in follow-up on time, unwilling to submit to the randomization process, or unable to return to scheduled protocol visits; 2) Participated in another clinical trial within 3 months; 3) Prior intraocular laser therapy, prior intraocular surgery (including cataract surgery), or planned within the next 6 months; 4) A history of poorly controlled glaucoma (defined as intraocular pressure =25mmHg after treatment with anti-glaucoma drugs); 5) Previously diagnosed with wet AMD, retinal vein obstruction and other neovascular retinopathy; 6) Patients diagnosed with premacular membrane, ischemic optic neuropathy, uveitis and other definite fundus diseases; 7) Patients with previous or current diagnosis of diabetic macular edema (OCT showed CST>=300um and BCVA180/110mmHg. Individuals are eligible if their blood pressure is maintained below 180/110 mmHg with antihypertensive medications; 17) A history of transient ischemic attack, stroke, myocardial infarction, acute congestive heart failure, or other acute cardiac events requiring hospitalization within the past 3 months; 18) For women of childbearing age: Potential study participants will be asked about becoming pregnant, breastfeeding or intending to become pregnant within the next 3 years. Researchers will determine when pregnancy tests are needed.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Best corrected visual acuity ;macular and optic disc thickness;macular and optic disc vessels density; | — |
Primary
| Measure | Time frame |
|---|---|
| posterior capsule opacification incidence rate; | — |
Countries
China
Contacts
Public ContactJuping Liu
Tianjin Medical University Eye Hospital
Outcome results
None listed