Intracranial aneurysms
Conditions
Interventions
Intervention group:oral aspirin enteric-coated tablet (100mg before breakfast for 6 months) + vitamin B1 tablet (1 tablet, before breakfast, for 6 months)
Control group:oral vitamin B1 tablet (1 tablet, before breakfast, for 6 months)
Sponsors
the First Affiliated Hospital of the Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Consent to enrollment and voluntary signing of the informed consent form; 2. Male or female, aged >= 18 years; 3. Diagnosis of intracranial aneurysm by any one or more of CTA, MRA, DSA; 4. TCD diagnosis of carotid atherosclerosis/plaque/stenosis; 5. The ability to live independently;
Exclusion criteria
Exclusion criteria: 1. Those with contraindications to MRI or MRA; 2. Persons with contraindications to oral aspirin, including but not limited to allergies, bleeding disorders, peptic ulcers, etc; 3. A history of SAH; 4. Have other intracranial vascular disease, including but not limited to arteriovenous malformations (AVMs), arteriovenous fistulas (AVFs), Moyamoya disease, etc; 5. Concomitant use of warfarin or other anticoagulants; 6. PLT < 100*10^9 /L; 7. Concomitant use of steroidal anti-inflammatory drugs, including but not limited to dexamethasone, hydrocortisone, etc. 8. Concomitant use of other non-steroidal anti-inflammatory drugs other than aspirin, including but not limited to diclofenac sodium, ibuprofen, celecoxib, etc; 9. Presence of other organ dysfunctions such as heart, liver and kidney, with an expected survival time of less than 1 year; 10. other patients deemed by the investigator to be unsuitable for inclusion in this study group
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of CRstalk ;Changes of Ktrans ;The stenosis of carotid diameter >= 50% with TIA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the number of aneurysms ;Morphological changes of aneurysms;The rupture of aneurysms;The stenosis of carotid diameter >= 70%; | — |
Countries
China
Contacts
Public ContactXia Li
the First Affiliated Hospital of the Air Force Medical University
Outcome results
None listed