Heart failure
Conditions
Interventions
Machine Learning - Heart Failure Group:None
Omics Analysis - Heart Failure Group:None
Omics Analysis - Healthy Control Group:None
Sponsors
The Chinese People's Liberation Army General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Heart failure enrollment: 1. Male or female, aged 18-90 years; 2. For the diagnosis of heart failure, refer to the 2021 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure, and meet the following conditions: (1) Symptoms and/or signs of heart failure: clinical symptoms such as difficulty breathing, fatigue, lower limb edema during rest or exercise, abnormal heart sounds, heart murmurs, lung rales, etc; (2) Objective examination of cardiac insufficiency: Left ventricular ejection fraction (LVEF) = 50%, but serum natriuretic peptide levels increase (BNP > 35ng/L and/or NT proBNP >125ng/L in patients without atrial fibrillation; BNP > 105ng/L and/or NT proBNP > 365ng/L in patients with atrial fibrillation), and meet at least one of the following criteria: left ventricular hypertrophy and/or left atrial enlargement; Abnormal diastolic function of the heart. 3. Diagnosis of metabolic syndrome: refer to the definition of metabolic syndrome in the Guidelines for Type 2 diabetes in China formulated by the diabetes Branch of the Chinese Medical Association, and use BMI instead of waist circumference to indicate obesity diagnosis, which meets the following three or more conditions: (1) Obesity: BMI >= 28 kg/m2; (2) Hyperglycemia: fasting blood glucose (FBG) >= 6.1 mmol/L and/or those who have been diagnosed with diabetes and treated; (3) Elevated blood pressure: systolic blood pressure >= 130/85mmHg and/or diagnosed with hypertension and treated; (4) Fasting TG >= 1.70 mmol/L; (5) Fasting HDL-C < 1.04 mmol/L; 4.The healthy control group excludes individuals found to have obvious systemic diseases or severe metabolic disorders during physical examination. 5.Participants must agree to sign the informed consent form and complete the collection of blood and stool samples.
Exclusion criteria
Exclusion criteria: 1. Pregnant women; 2. Malignant tumors or connective tissue diseases; 3. Severe hepatic or renal insufficiency; 4. Acute admissions clearly due to factors such as acute myocardial infarction, acute pulmonary embolism, hypertensive emergencies, or other stressors; 5. Presence of factors that may significantly affect the structure or function of the gut microbiota: chronic inflammatory bowel disease, history of chronic diarrhea or constipation, hereditary intestinal diseases, parenteral nutrition support, malabsorption syndrome, recent heavy consumption of yogurt products, and use of medications that may affect the gut microbiota within the past 3 months (such as probiotics, gastrointestinal motility regulators, or antibiotics, etc.); 6. Individuals unable to cooperate with enrollment and out-of-hospital follow-up for various reasons or with incomplete clinical data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac readmission;Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) Risk Score;Cardiovascular death;Non-fatal myocardial infarction/stroke; | — |
Countries
China
Contacts
Public ContactHe Kunlun
The Chinese People's Liberation Army General Hospital
Outcome results
None listed