Schizophrenia
Conditions
Interventions
one:active iTBS
Two:sham iTBS
Sponsors
Beijing Anding Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: (1) Meets DSM-5 diagnostic criteria for schizophrenia. (2) Age 18-50, either gender, right-handed, with at least 8 years of education. (3) Negative symptoms scale of PANSS score >= 21, with a score of >= 4 on any one item from N1 to N7. (4) Within the 2 weeks prior to intervention, a reduction of <10% in the PANSS negative symptom scale score. (5) The antipsychotic medication regimen (type and dosage) should remain unchanged for at least 4 weeks prior to study inclusion. (6) The Positive and Negative Syndrome Scale (PANSS) positive symptom scale score is <20, with a score of <4 on each of the items P1-P4. (7) The antipsychotic medication regimen (type and dosage) should remain unchanged until the end of the study. (8) Calgary Depression Scale for Schizophrenia (CDSS) score <6. (9) Signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Contraindication to rTMS, such as the presence of metal objects near the scalp, including intracranial metal implants, cochlear implants, and implanted pulse generators (e.g., deep brain stimulators or cardiac pacemakers). (2) IQ 2mg/day, diazepam > 10mg/day). (8) Clear history of epilepsy or previous seizures. (9) Received stimulants (e.g., methylphenidate, modafinil, or amphetamines), electroconvulsive therapy, rTMS, or other non-invasive brain stimulation treatments within the past 6 months. (10) Inability or unwillingness to cooperate with effective assessment and treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PANSS negative symptom subscale;the score of SANS; | — |
Secondary
| Measure | Time frame |
|---|---|
| the score of CAINS;PANSS positive symptom subscale;CGI;PANSS general symptom subscale;The score of CDSS;the score of PSP;the score of MCCB;fMRI; | — |
Countries
China
Contacts
Public ContactChuanyue Wang
Beijing Anding Hospital Affiliated to Capital Medical University
Outcome results
None listed