Aphasia
Conditions
Interventions
control group :Constraint-induced language therapy
treatment group1:Repetitive transcranial magnetic stimulation was performed immediately after constraint-induced language therapy.
treatment group2:Constraint-induced language therapy was completed immediately after repetitive transcranial magnetic stimulation
Sponsors
Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center)
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Screening of male and female subjects aged 18 to 85 years; 2. Willing and able to provide informed consent, provided by a legally authorized representative; 3. Cerebral stroke in the left hemisphere for the first time and clear lesions detected by craniocerebral CT or MRI scan; 4. Can maintain attention for 30min or more with a little reminder; 5. Be diagnosed as aphasia by the Western Aphasia Test (Chinese Version), AQ<93.8; 6. Have certain listening and understanding ability, and WAB's correct rate of Yes/No questions is not less than 50%; 7. Cognitive function assessment showed working memory impairment; 8. Proficient in or able to understand Mandarin before stroke; 9. Neuropharmacology was stable during study participation, with no adjustment in drug type and dosage.
Exclusion criteria
Exclusion criteria: 1. Other neurological diseases that may lead to cognitive or language impairment, such as Parkinson's disease, brain trauma, dementia; 2. Other diseases may cause the patient to be unable to complete the 2-hour training or to cooperate with other patients, such as hearing and vision impairment, obvious disturbance of consciousness, and mental abnormality; 3. rTMS cannot be performed due to internal stent, intracranial metal or skull defect; 4. The non-language based cognitive assessment (NLCA) showed significant cognitive impairment, total score<10 points; 5. A history of epileptic seizures, a woman in pregnancy, or a long history of alcohol or drug abuse; 6. Severe aphasia or combined with severe speech apraxia or severe dysarthria: ? Unable to imitate any pronunciation or unable to say any simple words under visual cues; ? Most of the expressions were neologism or paraphasia, and could not make correct responses under the guidance of the therapist; ? Combined with significant dysarthria, resulting in a significant reduction in speech articulation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aphasia quotient; | — |
Secondary
| Measure | Time frame |
|---|---|
| Picture naming;Verbal fluency;Functional communication;Working memory; | — |
Countries
China
Contacts
Public ContactQian qian
Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center)
Outcome results
None listed