Resistant Hypertension
Conditions
Interventions
Resistant hypertension:ozone-mediated lumbar sympathetic denervation (OL-SDN)
Sponsors
Jinan University affiliated Guangzhou Red Cross Hosptal
Eligibility
Sex/Gender
All
Age
43 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Written informed consent must be obtained before any assessment is performed. 2.Male and female patients, age 18 to 80 years inclusive 3.Confirmed diagnosis of resistant hypertension (RH) in accordance with the American Heart Association scientific statement, i.e.to have a mean systolic blood pressure of =130 mmHg on 24-hour ambulatory blood pressure monitoring and/or =135 mm Hg during the day time hours, while taking maximally tolerated doses of at least three antihypertensive agents including a diuretic; or to have a controlled blood pressure with four or more antihypertensive agents.
Exclusion criteria
Exclusion criteria: 1.Patients with confirmed secondary hypertension (all-caused renal artery stenosis; adrenal pheochromocytoma; cushing disease; primary hyperaldosteronism; occluded sleep apnea syndrome (OSAS) ). 2.Patients with spine malformation, spine infective disease. 3.Patients with history of renal artery angioplasty or denervation. 4.Patients with history of lumber internal vertebra disc frequency ablation and sympathetic blockage. 5.Myocardial infarction / Cerebral Vascular Accident (CVA) / TIA within the past three months prior to enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in 24-hour ambulatory SBP (from baseline to 12 weeks); | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction in category numbers of anti-hypertensive drugs;Control rate of home BP ;Incidence of AEs; | — |
Countries
China
Contacts
Public ContactLi Li
Jinan University, Guangzhou Red Cross Hospital
Outcome results
None listed