ventilator-associated lung injury
Conditions
Interventions
Group of breathing training (Part II experiment):Lung-protective ventilation and postoperative breathing training
Group of Control (Part I experiment):Traditional ventilation strategies
Group of traditional lung-protective ventilation (Part I experiment):Traditional lung-protective ventilation strategies
Group of innovative lung-protective ventilation (Part I experiment):Innovative lung-protective ventilation strategies
Group of traditional & innovative ventilation (Part I experiment):Traditional & innovative lung protection ventilation strategy
Group of Control (Part II experiment):Lung-protective ventilation and negative pressure extubation
Group of positive pressure extubation (Part II experiment):Lung-protective ventilation and positive pressure extubation
Group of positive pressure extubation & breathing training (Part II experiment):Lung-protective ventilation & positive pressure extubation & postoperative respiratory training
Sponsors
Fujian Medical University Union Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Elderly patients aged >= 60 years old who undergo laparoscopic abdominal surgery; 2. BMI = 94%; 5. The duration of the operation is 2-7 h, and the pneumoperitoneal pressure is 10-14 mmHg.
Exclusion criteria
Exclusion criteria: 1.Patients with ARDS or pulmonary hypertension (pulmonary systolic blood pressure >= 40mmHg) or bronchiectasis or lung malignant tumors; 2.Patients who have had an acute respiratory infection or who have had cardiopulmonary surgery within one month before surgery; 3.Receiving invasive mechanical ventilation for more than 30min within 30 days before surgery; 4.Mechanical ventilation airway peak pressure >= 35 cmH2O; 5.Patients with severe organic lesions of the heart such as obvious heart failure and coronary heart disease; 6.Patients with preoperative anemia (Hb = 3 hours); 11.Patients with mental illness, impaired consciousness and communication disorders; 12.Patients who refuse to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Volume ratio of new-onset atelectasis after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Signature indicator of ventilator-related lung injury;Oxygenation index;Postoperative pulmonary complications;Other postoperative complications; | — |
Countries
China
Contacts
Public ContactZhongmeng Lai
Fujian Medical University Union Hospital
Outcome results
None listed