Clinical study of botulinum toxin type A combined with hyaluronic acid in the treatment of mid-cheek groove

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300071360

Enrollment

Unknown

Registered

2023-05-12

Start date

2023-06-05

Completion date

Unknown

Last updated

2023-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mid-cheek groove

Interventions

Treatment group:The treatment is divided into two stages. Phase 1: The patient is treated with Botox injections, i.e. 2u of Botox at the intersection of the medial canthus and the tear trough. Phase 2

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: ? Patient's subjective expression of willingness to undergo mid-buccal sulcus treatment ? Age: 18-60 years ? Refer to WSRS mid-buccal sulcus classification of II, III, IV ? Male or female only ? Signed informed consent form

Exclusion criteria

Exclusion criteria: ? allergic, allergic to the ingredients in the injectable solution ? have undergone facial aesthetic treatment within one year, including Botox, hyaluronic acid, laser, etc. ? infected or broken skin at the injection site ? Previous neuromuscular pathology such as multiple sclerosis, myasthenia gravis, etc. ? Women who are pregnant or breastfeeding ? Other conditions considered inappropriate for inclusion

Design outcomes

Primary

Measure	Time frame
Depth of mid-cheek groove;	—

Countries

China

Contacts

Public ContactGuangshuai Li

The First Affiliated Hospital of Zhengzhou University

liguangshuai@zzu.edu.cn+86 13838062386

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026