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Low dose Esketamine combined with dexmedetomidine for the prevention and treatment of traction reactions in combined spinal-epidural anesthesia during cesarean section

Low dose Esketamine combined with dexmedetomidine for the prevention and treatment of traction reactions in combined spinal-epidural anesthesia during cesarean section

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300071350
Enrollment
Unknown
Registered
2023-05-12
Start date
2023-05-12
Completion date
Unknown
Last updated
2023-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

traction response

Interventions

blank group:The blank group only used lumbar epidural anesthesia
Ketodex group:The Ketodex group also used lumbar epidural anesthesia to achieve a anesthesia level of T6. Then, after fetal delivery and clamping of the umbilical cord, a mixed solution of 0.3mg/kg of
Dexmetomidine group:The metomidine group was anesthetized using a combination of lumbar and epidural anesthesia, with the anesthesia level reaching T6. Then, after fetal delivery and clamping of the u

Sponsors

The Third Affiliated Hospital of Sun Yat sen University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: (1) Pregnant and postpartum women who require spinal anesthesia for cesarean section due to various reasons; (2) The patient voluntarily participates and signs an informed consent form; (3) Age 18-40 years old; (4) ASA I-II level.

Exclusion criteria

Exclusion criteria: (1) Preeclampsia and eclampsia; (2) Patients with poor control or untreated hypertension; (3) Untreated or insufficiently treated hyperthyroidism patients; (4) Uterine rupture, umbilical cord prolapse, etc

Design outcomes

Primary

MeasureTime frame
Incidence of traction pain;

Secondary

MeasureTime frame
The incidence of other adverse events during surgery;

Countries

China

Contacts

Public ContactHuang Pinjie

The Third Affiliated Hospital of Sun Yat sen University

hpjie@126.com+86 137 2409 0424

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026