keloid
Conditions
Interventions
Study Group:carrier-free 5-fluorouracil nanoparticles + carbon dioxide laser
negative control:Pure 5-fluorouracil +carbon dioxide laser
Positive control group:triamcinolone acetonide+carbon dioxide laser
Sponsors
The Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: The course of the disease exceeds six months; Scars are in a stable stage; Confirming compliance with the morphological characteristics of hypertrophic scars and meeting the diagnostic criteria for hypertrophic scars; Diagnosed as keloid (with an area less than 10cm2), with scar hyperplasia extending beyond the original injured area and showing tumor like growth; ? Age range from 20 to 50 years old 3 (4) This study was approved by the hospital ethics committee, and patients were informed in detail about the potential advantages and disadvantages before and after medication. Patients and their families voluntarily chose treatment plans and signed informed consent forms.
Exclusion criteria
Exclusion criteria: (1) Those who have received laser or related hormone therapy within the past year; (2) Individuals who are allergic to corticosteroids or lasers; (3) There are basic diseases such as diabetes, hyperthyroidism, or abnormal blood coagulation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| POSAS Scar Evaluation Scale (Patient + Doctor);vancouver scar scale;Laser speckle instrument;Skin ultrasound instrument; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient self-assessment and observer assessment; | — |
Countries
China
Contacts
Public ContactLi Ying
Affiliated Hospital of Southwest Medical University
Outcome results
None listed