severe periodontitis
Conditions
Interventions
Control Group:Subgingival scaling and Root Planing
Low concentration group:Subgingival scaling and Root Planing+oral vitamin D3 1000IU/d
High concentration group:Subgingival scaling and Root Planing+oral vitamin D3 2000IU/d
Sponsors
Department of periodontology, School of Stomatology, China Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Severe periodontitis, stage III or IV (new classification by European Union of Periodontology and American Academy of Periodontology), PD=6mm, maximum loss of interdental attachment =5mm, X-ray alveolar bone resorption More than 1/3 of the root length; (2) Age: 18-60 years old; (3) More than 20 natural teeth remaining in the oral cavity; (4) The subjects have not received periodontal system treatment within 6 months.
Exclusion criteria
Exclusion criteria: (1) smoking; (2) female pregnancy and lactation; (3) taking antibiotics and non-steroidal anti-inflammatory drugs within the past 3 months; (4) other systemic diseases that affect periodontal tissue (high blood pressure, AIDS, rheumatoid, tumor, etc.); (5) suffering from hypercalcemia and malabsorption syndrome; (6) taking any vitamin D and its analog supplements and/or calcium drugs before and at the current stage of the study; (7) Are using drugs that may interfere with vitamin D metabolism (such as phenobarbital, phenytoin, and glucocorticoids); (8) Have been exposed to direct sunlight for more than three hours a day or have used UV sunbathing within two months (9) intake of any other nutritional supplements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum 25(OH)D levels;gingival crevicular fluid 25(OH)D levels;probing depth;clinical attachment level;Sulcus Bleeding Index;bleeding on probing;tooth mobility;Serum MMP-8 levels;gingival crevicular fluid MMP-8 levels;Serum IL-1ß levels;gingival crevicular fluid IL-1ß levels;Serum IL-4 levels;gingival crevicular fluid IL-4 levels;Serum OC levels;gingival crevicular fluid OC levels;Serum ALP levels;gingival crevicular fluid ALP levels;Serum RANKL levels;gingival crevicular fluid RANKL levels; | — |
Countries
China
Contacts
Public ContactXiaolin Tang
Department of periodontology, School of Stomatology, China Medical University
Outcome results
None listed