paresthesia
Conditions
Interventions
Interventional group:lidocaine+fospropofol disodium
Control group:fospropofol disodium
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) 65 years old = 18 years old, BMI=18-30kg/m2, ASA I-III; (2) Patients undergoing elective general anesthesia surgery and requiring tracheal intubation for non cardiothoracic and non extracerebral surgeries; (3) No mental illness, chronic itching, or sensory abnormalities; (4) Sign an informed consent form and agree to be included in the study.
Exclusion criteria
Exclusion criteria: (1) Individuals with contraindications to general anesthesia or those who have experienced anesthesia accidents in the past; (2) Those who need to combine other anesthesia methods besides general anesthesia, such as epidural anesthesia, subarachnoid anesthesia, nerve block, etc; (3) Individuals with difficult airways or diagnosed with difficulty in tracheal intubation (modified Markov score of III or IV) (4) Concomitant neurological and psychiatric disorders: such as craniocerebral injury, intracranial hypertension, stroke, or previous history of mental illness; (5) Abnormal liver function (ALT or AST = 2.5 times the upper limit of normal value, TBIL = 1.5 times the upper limit of normal value), abnormal renal function (Cr>the upper limit of normal value, or dialysis treatment within 28 days before surgery); Uncontrolled diabetes or hypertension; (6) Individuals with allergies or contraindications to experimental drugs or other anesthetic drugs; (7) Individuals who have participated in any drug clinical trial within one month prior to screening; (8) The researchers believe that subjects with any other unfavorable factors for participating in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rate of paresthesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| VRS score of pruritus;Pain at the administration site;Duration of disappearance of eyelash reflex;The incidence of hypotension and bradycardia during anesthesia induction period;Blood pressure, heart rate and BIS during anesthesia induction;Success rate of anesthesia induction;Vital signs during anesthesia maintenance period;Recovery period related indicators;Perioperative adverse reactions;the first administration time of maintain medication;blood sample test; | — |
Countries
China
Contacts
Public ContactChen Chan
West China Hospital of Sichuan University
Outcome results
None listed