cognitive impairment
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 110 Years
Inclusion criteria
Inclusion criteria: From March 2023, the population of cognitive risk assessment in the First Affiliated Hospital of Wenzhou Medical University and the population participating in the cognitive census of Wenzhou City were selected. 1) Age =45 years old. 2) Clinical presentation: Cognitive decline (impairment of memory, executive, language or visuospatial ability) or abnormal mental behavior, affecting the ability to work or daily life. 3) The subjects had good audio-visual function and language function or could complete the neuropsychological examination after correction. 4) The subjects and those with knowledge can complete the relevant examination and follow-up work. 5) Informed consent was signed by the subjects or their authorized principals.
Exclusion criteria
Exclusion criteria: 1) Patients with a history of stroke and focal neurological signs and neuroimaging findings consistent with cerebral small vessel disease (Fazekas score =2). 2) Presence of other neurological diseases that can cause brain dysfunction (such as depression, brain tumors, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.). 3) There are other systemic diseases that can cause cognitive impairment, such as liver dysfunction, renal dysfunction, thyroid dysfunction, severe anemia, folate and vitamin B12 deficiency, specific infections (such as syphilis, HIV), alcohol and drug abuse, etc. 4) There is mental and neurodevelopmental delay. 5) Other conditions exist that are known to cause cognitive impairment. 6) Contraindications to MRI exist. 7) An inability to cooperate in completing a cognitive examination. 8) Refusing to draw blood. 9) The screening period refused to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ApoE;brain magnetic resonance imaging;Laboratory index;Cognitive and living ability assessment questionnaire; | — |
Secondary
| Measure | Time frame |
|---|---|
| Color ultrasound;ambulatory blood pressure;eye-ground photography; | — |
Countries
China
Contacts
Public ContactGaojun Wu
the First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed