burn
Conditions
Interventions
Gold Standard:Gold standard: Gastrointestinal endoscopic exploration reveals intestinal injury.
Reference criteria: The patient showed symptoms of intestinal injury, with elevated blood inflammation i
Index test:Reverse transcription-fluorescence quantitative polymerase chain reaction (qRT-PCR) was used to detect long chain non-coding RNABmp1.
Sponsors
the 71st Group Army Hospital of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients were =18 years old and =70 years old, and their gender was not limited; The total burn area of severe burn group was =30%TBSA and =80%TBSA, or the total burn area of ? degree burn area was =10%TBSA and =30%TBSA (the burn area was calculated by the Chinese nine-point method, and the burn depth was determined by the three-degree four-point method); The cause of admission was burn. He was admitted to the Burn and Plastic Department of the 71st Army Military Hospital within 24 hours after the injury and received regular and complete burn treatment. The burn wound was not infected upon admission. No death occurred within 24 hours of admission; The subjects in the severe burn group and the healthy control group had no previous history of gastrointestinal diseases (such as acute and chronic gastritis, peptic ulcer, inflammatory bowel disease, functional gastrointestinal disease, gastric perforation, upper gastrointestinal bleeding, etc.).
Exclusion criteria
Exclusion criteria: Previous and present history indicate the presence of gastrointestinal diseases (such as acute and chronic gastritis, peptic ulcer, inflammatory bowel disease, functional gastrointestinal disease, gastric perforation, upper gastrointestinal bleeding, acute and chronic pancreatitis, intestinal obstruction, etc.); Severe metabolic disease with severe dyspepsia or severe malabsorption, or combined with tumor; Chronic respiratory diseases, cardiovascular diseases or chronic kidney diseases, autoimmune diseases and other immune dysfunction, diabetes, etc.; A woman who is pregnant or breastfeeding; Long-term use of non-steroidal anti-inflammatory drugs (such as indomethacin, aspirin, etc.), glucocorticoids, sirolimus, bisphosphonates, clopidogrel and other drugs before admission; The patient has a family history of peptic ulcers or other gastrointestinal disorders. Patients had poor compliance or mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Long non-coding RNA Bmp1;cast-off cells;specificity;sensitivity;accuracy;Area under the curve of the receiver operating characteristic curve;cut off value ; | — |
Secondary
| Measure | Time frame |
|---|---|
| LPS;IL-6;TNF-a;DAO;D-lactic acid;L/M; | — |
Countries
China
Contacts
Public ContactYong Sun
the 71st Group Army Hospital of PLA
Outcome results
None listed