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Effect of enteral nutrition containing partially hydrolyzed guar gum (PHGG) dietary fiber on gut microbiota in patients with brain hemorrhage

Effects of different enteral nutrients on intestinal flora in patients with severe neurological symptoms

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300071308
Enrollment
Unknown
Registered
2023-05-11
Start date
2023-05-07
Completion date
Unknown
Last updated
2023-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain hemorrhage

Interventions

PHGG group:A full dose of enteral nutrition containing PHGG was used for 7 days
Control group:A full dose of enteral nutrition without PHGG was used for 7 days

Sponsors

Department of Neurosurgery, Chinese Academy of Sciences, Peking Union Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1) Glasgow Coma (GCS) score =13; Patients were diagnosed with cerebral hemorrhage lesions (including parenchymal hemorrhage, subarachnoid hemorrhage, subdural hemorrhage, and ruptured cerebral arteriovenous tumor). 2) NUTRIC score greater than 5; 3) Age >18 years old; 4) Unable to eat ordinary food after assessment; 5) Patients or family members sign informed consent;

Exclusion criteria

Exclusion criteria: 1) Patients with severe vomiting, abdominal distension and diarrhea after receiving enteral nutrition support, and cannot tolerate it; 2) Patients with severe digestive tract diseases, patients with severe liver and kidney function impairment, patients with serious endocrine diseases, patients with cardiac insufficiency, and patients with severe low immunity; 3) Patients with injuries outside other vital organs; 4) There have been major dietary adjustments in the past week; 5) During pregnancy or lactation; 6) Received antibiotics or probiotics in the last 1 month; 7) Refuse to participate in the study;

Design outcomes

Primary

MeasureTime frame
Fecal sequencing;Serum metabolic mass spectrometry;

Countries

China

Contacts

Public ContactXiao ZHANG

Peking Union Medical College Hospital, Chinese Academy of Sciences

zhang200026@126.com+86 186 1170 4266

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026