Effect of opioid-free anesthesia on the postoperative quality of recovery after laparoscopic hysterectomy

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300071297

Enrollment

Unknown

Registered

2023-05-10

Start date

2023-05-22

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gynecopathy

Interventions

opioid-free group:dexmedetomidine in a loading dose of 1ug/kg within 10 mins before induction

esketamine 0.5mg/kg for induction

dexmedetomidine for maintenance.

opioid-based group:an equivalent volume of saline infusion followed by sufentanil 0.5 µg/kg for induction

remifentanil for maintenance.

Eligibility

Sex/Gender

Female

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-65 years; 2. Patients scheduled for laparoscopic hysterectomy; 3. American society of anesthesiologists phisical status I-II.

Exclusion criteria

Exclusion criteria: 1. The patient refuses to participate; 2. Allergic to investigational drugs (e.g. Dexmedetomidine, esketamine, remifentanil, etc.); 3. Pregnant patients or breastfeeding; 4. A history of chronic pain or use of painkillers within 48 hours before surgery; 5. Sick sinus syndrome or degree II or III atrioventricular block; 6. Patients with poorly controlled or untreated hypertension (systolic blood pressure >180 mmHg or diastolic blood pressure >100 mmHg); 7. Mental illness or cognitive impairment.

Design outcomes

Primary

Measure	Time frame
15-item Quality of Recovery Scale Score;	—

Secondary

Measure	Time frame
PONV incidence;Opioid consumption ;Pain intensity score;Emergence time;Length of PACU stay;	—

Countries

China

Contacts

Public ContactYusheng Yao

Fujian Provincial Hospital

fjslyys@126.com+86 135 5993 9629

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 4, 2026