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Application of metagenomic next-generation sequencing (mNGS) in infected pancreatic necrosis: a multicenter prospective clinical study

Application of metagenomic next-generation sequencing (mNGS) in infected pancreatic necrosis: a multicenter prospective clinical study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300071292
Enrollment
Unknown
Registered
2023-05-10
Start date
2023-05-20
Completion date
Unknown
Last updated
2023-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infected pancreatic necrosis (IPN)

Interventions

Gold Standard:bacteria/fungal culture of peripancreatic necrotic effusion
Index test:metagenomic next-generation sequencing (mNGS)

Sponsors

Xiangya Hospital Central South University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
14 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria for acute pancreatitis; 2. On admission, enhanced CT scan showed necrosis of pancreas and/or peripancreatic tissue; 3. Body temperature greater than or equal to 38.5 degrees Celsius during the course of the disease; 4. No invasive intervention was performed; 5. Aged >=14 years.

Exclusion criteria

Exclusion criteria: 1. Midway withdrawal (patient withdraws informed consent) or data loss; 2. Primary infection of other systems has been identified, such as lung infection and nervous system infection.

Design outcomes

Primary

MeasureTime frame
sensitivity;specificity;positive predictive value;negative predictive value;—

Countries

China

Contacts

Public ContactHuang Gengwen

Xiangya Hospital Central South University

1466471168@qq.com+86 159 7419 4750

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026