irritable bowel syndrome (IBS)
Conditions
Interventions
Experimental group:Oral administration of fecal bacteria capsules
Sponsors
Chinese People's Liberation Army General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Nationality: Chinese; 2. Aged 18-60 years; 3. Meet the Rome IV diagnostic criteria for each subtype of IBS.
Exclusion criteria
Exclusion criteria: 1. History of antibiotics and/or immunosuppressants and/or probiotics and/or laxatives (including diet drugs) within the last 3 months; 2. Patients with congenital or acquired immune deficiency or severe immunosuppression (neutrophils <1500 /mm^3, lymphocytes <500 /mm^3); 3. Severe damage of intestinal mucosa or failure to identify the cause of intestinal mucosal injury; 4. Currently diagnosed with fulminant colitis or toxic megacolon; 5. Enteral nutrition patients who cannot tolerate 50% of heat calorie requirements due to severe diarrhea, significant fibrous intestinal stricture, severe gastrointestinal bleeding, high-flow intestinal fistula, etc.; 6. Patients with parenteral organ infection requiring broad-spectrum antibiotic intervention; 7. Patients with severe malnutrition (body mass index <15kg/m^2) and severe hypoproteinemia (albumin <25g/L); 8. Patients with severe allergies; 9. Patients who are preparing for pregnancy or during pregnancy or breastfeeding; 10. Patients who are unable to take care of themselves or have serious psychological or mobility disorders and cannot actively cooperate with the completion of intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IBS symptom severity scale, IBS-SSS;IBS quality of life, IBS-QoL;objective remission rate;16s RNA gut microbiota health assessment;physiological index detection;effectiveness evaluation; | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse reaction; | — |
Countries
China
Contacts
Public ContactZeng Qiang
The Second Medical Center and National Clinical Research Center for Geriatric Disease, Chinese People's Liberation Army General Hospital
Outcome results
None listed